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名稱	Recombinant Human FGF-basic （154 a.a.）
型號
更新時(shí)間	2023-09-24
特點(diǎn)	FGF-basic是23已知FGF家族的成員之一。這個(gè)家庭中發(fā)揮核心作用的蛋白質(zhì)在產(chǎn)前發(fā)展和產(chǎn)后的生長和再生各種組織,通過促進(jìn)細(xì)胞增殖和分化。FGF-basic non-glycosylated肝素結(jié)合生長因子,表示在大腦中,垂體,腎、視網(wǎng)膜、骨頭、睪丸、腎上腺肝、單核細(xì)胞、上皮細(xì)胞和內(nèi)皮細(xì)胞。重組人類FGF-basic 17.2 kDa蛋白由154個(gè)氨基酸殘基組成。使用所有無動(dòng)物生產(chǎn)試劑。}

詳細(xì)內(nèi)容

一.產(chǎn)品名稱：Recombinant Human FGF-basic

二.貨號Catalog Number:AF-100-18B

三.同義Synonyms:Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin

四.描述Description:

FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Manufactured using all non-animal reagents.

五.AA序列AA Sequence:

AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS

六.來源Source:E.coli

七.純度Purity:Greater than 95% by SDS-PAGE gel and HPLC analyses.

八.生物活性Biological Activity:

Assay #1: The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 0.5ng/ml corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.

Assay #2: The ED₅₀ was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

九.交叉性Cross Reactivity:

Cow, Dog, Frog, Hamster, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Human + Mouse, Rat + Chicken, Human, Chicken, Horse, N/A, Human + Virus

十.產(chǎn)地：美國Peprotech