| 名稱 | Recombinant Human IL-4 |
| 型號 | |
| 更新時間 | 2023-09-24 |
| 特點 | IL-4是一種多效性的細胞因子,調節不同的T細胞和B細胞的反應包括細胞增殖、生存和基因表達。以IL-4 cytokine-secretion概要,包括分泌,IL-5,il - 6、il - 10和IL-13體液免疫反應。IL-4的另一個主要功能是調節免疫球蛋白類切換到IgG1和IgE isotypes。重組人類IL-4 15.1 kDa球狀蛋白質含有130個氨基酸殘基。使用所有無動物生產試劑。} |
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- 詳細內容
一.產品名稱：Recombinant Human IL-4/重組IL-4
二.Catalog Number:AF-200-04
三.Synonyms:BCGF, BCDF, B cell stimulating factor (BSF-1)
四.Description:
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues. Manufactured using all non-animal reagents.
五.AA Sequence:
MHKCDITLQE IIKTLNSLTE QKTLCTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
六.Source:E.coli
七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
九.Cross Reactivity:Human, Mouse
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電話/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室